CHD8 is an ATP-dependent chromatin-remodeling factor whose monoallelic mutation defines a subtype of autism spectrum disorders (ASDs). Previous work found that CHD8 is required for the maintenance of hematopoiesis by integrating ATM-P53-mediated survival of hematopoietic stem/progenitor cells (HSPCs). Here, by using Chd8^(F/F)Mx1-Cre combined with a Trp53^(F/F) mouse model that suppresses apoptosis of Chd8^(-/-) HSPCs, we identify CHD8 as an essential regulator of erythroid differentiation....